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  • Human CD112/Nectin-2/PVRL2 (His Tag) recombinant protein

Human CD112/Nectin-2/PVRL2 (His Tag) recombinant protein

Cat.#: 503233

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Product Information

  • Product Name
    Human CD112/Nectin-2/PVRL2 (His Tag) recombinant protein
  • Documents
  • Description
    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
  • Protein name
    Nectin-2
  • Protein short names
    MPH; AI987993; PRR2; PVS; HVEB; PVRR2; CD112; NECTIN-2; MHVEB; AI325026; PVRL2; PVR
  • Uniprot ID
    Q92692
  • Gene Name
    PVRL2; HVEB; PRR2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Leu 360) of human CD112 (NP_002847.1) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The recombinant mature human CD112 consists 340 amino acids and has a calculated molecular mass of 36.2 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 48 kDa protein in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized recombinant human CD112 at 20 μg/ml (100 μl/well) can bind biotinylated DNAM1 with a linear range of 0.078-2.5 μg/ml.
  • Validations

    Human CD112 / Nectin-2 / PVRL2 Protein (His Tag) SDS-PAGE

    Human CD112 / Nectin-2 / PVRL2 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"