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  • Human NECTIN2/HVEB/PRR2/PVRL2 (His tag) recombinant protein

Human NECTIN2/HVEB/PRR2/PVRL2 (His tag) recombinant protein

Cat.#: 518552

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Product Information

  • Product Name
    Human NECTIN2/HVEB/PRR2/PVRL2 (His tag) recombinant protein
  • Documents
  • Description
    CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.
  • Protein name
    nectin cell adhesion molecule 2(NECTIN2)
  • Protein short names
    HVEB; PRR2; PVRL2
  • Uniprot ID
    Q92692
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human NECTIN2/HVEB/PRR2/PVRL2 Gln32-Leu360 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human NECTIN2/HVEB/PRR2/PVRL2 (His tag) recombinant protein

    Human NECTIN2/HVEB/PRR2/PVRL2 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"