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Gelsolin antibody

Cat.#: 110936

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Product Information

  • Product Name
    Gelsolin antibody
  • Documents
  • Description
    Gelsolin Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, human liver tissue. Positive IHC detected in human prostate cancer tissue. Observed molecular weight by Western-blot: 87-93 kDa
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Actin depolymerizing factor antibody; ADF antibody; AGEL antibody; Brevin antibody; DKFZp313L0718 antibody; Gelsolin antibody; GSN antibody
  • Immunogen
    Human Gelsolin Recombinant protein (GST tag)
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Gelsolin recombinant protein (Accession Number: NM_000177). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS only, pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:110936(GSN antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:110936(GSN antibody) at dilution of 1:50 (under 10x lens)

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:110936(Gelsolin Antibody) at dilution of 1:1000

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:110936(Gelsolin Antibody) at dilution of 1:1000

  • Background
    Gelsolin (GSN) is an actin binding protein that regulates actin-severing/depolymerizing in a calcium dependent manner, and acts as a multifunctional regulator for cell metabolism and survival. Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and a plasma gelsolin (pGSN; 93 kDa), differing at N terminal residues. Decreased levels of pGSN are strongly associated with human diseases, such as, acute liver injury, major trauma, myocardial infarction, inflammation, lung injury, rheumatoid arthritis, hemodialysis, multiple sclerosis, Alzheimer's disease.
  • References
    • Wu J, Meng J, Du Y. RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway. Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie. 67(4):313-9. 2013.
    • Deng B, Fang J, Zhang X, Qu L, Cao Z, Wang B. Role of gelsolin in cell proliferation and invasion of human hepatocellular carcinoma cells. Gene. 571(2):292-7. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"