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Gelsolin antibody

Cat.#: 107294

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Product Information

  • Product Name
    Gelsolin antibody
  • Documents
  • Description
    Gelsolin Mouse Monoclonal antibody. Positive IHC detected in human colon tissue, human colon cancer tissue. Positive WB detected in human plasma tissue, A549 cells. Observed molecular weight by Western-blot: 80-83 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    Actin depolymerizing factor antibody; ADF antibody; AGEL antibody; Brevin antibody; Gelsolin antibody; GSN antibody
  • Immunogen
    Human Gelsolin Recombinant protein (His tag)
  • Isotype
    IgA
  • Preparation
    This antibody was obtained by immunization of Gelsolin recombinant protein (Accession Number: NM_000177). Purification method: Thiophilic affinity chromatograph.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:1000-1:10000

    IHC: 1:20-1:200

  • Validations

    human plasma tissue were subjected to SDS PAGE followed by western blot with Catalog No:107294(Gelsolin Antibody) at dilution of 1:2000

    human plasma tissue were subjected to SDS PAGE followed by western blot with Catalog No:107294(Gelsolin Antibody) at dilution of 1:2000

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:107294(Gelsolin Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:107294(Gelsolin Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:107294(Gelsolin Antibody) at dilution of 1:200 (under 40x lens).

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:107294(Gelsolin Antibody) at dilution of 1:200 (under 40x lens).

  • Background
    Gelsolin (GSN) is an actin binding protein that regulates actin-severing/depolymerizing in a calcium dependent manner, and acts as a multifunctional regulator for cell metabolism and survival. Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and a plasma gelsolin (pGSN; 93 kDa), differing at N terminal residues. Decreased levels of pGSN are strongly associated with human diseases, such as, acute liver injury, major trauma, myocardial infarction, inflammation, lung injury, rheumatoid arthritis, hemodialysis, multiple sclerosis, Alzheimer's disease.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"