Human Follistatin (His Tag) recombinant protein

Cat.#: 500587

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Product Information

  • Product Name
    Human Follistatin (His Tag) recombinant protein
  • Documents
  • Description
    Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin, the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin, it is imperative to determine the nature of the activin/follistatin binding complex.
  • Protein name
    Follistatin, isoform CRA_c
  • Protein short names
    FST; FOLLISTATIN; FS; AL033346
  • Uniprot ID
    P19883
  • Gene Name
    FST; hCG_40892
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human FST (NP_037541.1) (Met1-Asp329) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human FST consists 311 amino acids and predicts a molecular mass of 34.4 kDa.
  • Purity
    > 85 % as determined by SDS-PAGE.
  • Activity
    Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.
    The ED50 for this effect is typically 5-40ng/mL.
  • Validations

    Human Follistatin / FST Protein (His Tag)

    Human Follistatin / FST Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"