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Product Name
Human DDR1/MCK10/CD167 (His Tag) recombinant protein
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Description
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
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Protein name
Epithelial discoidin domain-containing receptor 1
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Protein short names
6030432F18; PTK3; DDR1; MCK10; CD167; RTK6; PTK3A; CD167A; NEP; NTRK4; TRKE; DDR; EDDR1; CAK; HGK2; AI323681; DAAP-278B20.1
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Uniprot ID
Q08345
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Gene Name
DDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of human DDR1 isoform b (NP_001945.3) (Met 1-Thr 416) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The recombinant human DDR1 consists of 409 amino acids and has a calculated molecular mass of 45.7 kDa. The apparent molecular mass of rh DDR1 is approximately 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human DDR1 Kinase / MCK10 / CD167 Protein (His Tag) SDS-PAGE
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