Mouse DDR1/MCK10/CD167 (Fc Tag) recombinant protein

Mouse DDR1/MCK10/CD167 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

Epithelial discoidin domain-containing receptor 1

NEP; CD167A; TRKE; NTRK4; DDR; DAAP-278B20.1; HGK2; AI323681; CAK; EDDR1; PTK3; 6030432F18; DDR1; MCK10; RTK6; CD167; PTK3A

Q544T2

Ddr1; Cak; Eddr1; Mpk6

Human Cells

A DNA sequence encoding the extracellular domain of mouse DDR1 (NP_766550.1) (Met 1-Thr 414) was fused with the Fc region of human IgG1 at the C-terminus

Mouse

The secreted recombinant mouse DDR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 636 amino acids and has a calculated molecular mass of 71 kDa. As a result of glycosylation, the apparent molecular mass of rmDDR1/Fc monomer is approximately 80-90 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE