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Product Name
Cynomolgus p53/TP53 recombinant protein
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Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
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Protein name
Cellular tumor antigen p53
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Protein short names
TP53; FLJ92943; RP23-56I20.1; TRP53; BFY; P44; BBL; BHY; LFS1; P53
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Uniprot ID
E3U906
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Gene Name
TP53; EGK_08142
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Cynomolgus (Macaca fascicularis) p53 (E3U906) (Met 1-Asp 393) was expressed and purified.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant Cynomolgus p53 consisting of 393 amino acids and has a calculated molecular mass of 43.7 kDa. It migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 88 % as determined by SDS-PAGE
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Activity
1. Measured by its ability to bind biotinylated human S100B in a functional ELISA.
2. Measured by its ability to bind biotinylated human RRM2B in a functional ELISA. -
Validations
Cynomolgus p53 / TP53 Protein SDS-PAGE
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