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Product Name
Anti-Cytokeratin 18 (2B5) Mouse antibody
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Description
Cytokeratin 18 (2B5) Mouse monoclonal antibody
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Tested applications
WB, ICC/IF
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Species reactivity
Human, Monkey
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Alternative names
Cell proliferation inducing gene 46 protein;Cell proliferation inducing protein 46;Cell proliferation-inducing gene 46 protein;CK 18;CK-18;CK18;Cytokeratin 18;Cytokeratin endo B;Cytokeratin-18;Cytokeratin18;K 18;K18;K1C18_HUMAN;Keratin 18;Keratin D;Kerati antibody
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Isotype
IgG2a
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Preparation
Antigen: Purified recombinant human Keratin 18 protein fragments expressed in E.coli.
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Clonality
Monoclonal
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Formulation
Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide 0.1mg/mlBSA and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/2000
;ICC: 1/800
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Validations
Western blot detection of Keratin 18 in Hela,COS7 and 293T cell lysates using Keratin 18 mouse mAb (1:2000 diluted).Predicted band size:46KDa.Observed band size:46KDa.
Immunocytochemistry staining of HeLa cells fixed by anhydrous methanol for 2 h at -20u2103 and using anti-Keratin 18 mouse mAb (dilution 1:800).
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Background
Swiss-Prot Acc.P05783.Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"