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Product Name
Anti-beta 2 Microglobulin Rabbit antibody
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Description
beta 2 Microglobulin Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
IMD43 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human beta 2 Microglobulin
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/200
FC: 1/20
IP: 1/20
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Validations
Western blot detection of beta 2 Microglobulin in Hela cell lysates using beta 2 Microglobulin Rabbit pAb(1:1000 diluted).Predicted band size:14kDa.Observed band size:14kDa.
Immunohistochemistry of beta 2 Microglobulin in paraffin-embedded Human lung cancer tissue using beta 2 Microglobulin Rabbit pAb at dilution 1/50
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Background
Swiss-Prot Acc.P61769.Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"