-
Product Name
Rat PEDF (His Tag) recombinant protein
- Documents
-
Description
Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
-
Protein name
Alpha-2 antiplasmin
-
Protein short names
SERPINF1; EPC-1; PIG35; OI6; SDF3; AI195227; PEDF; OI12; RP23-384C18.1; PEDFL
-
Uniprot ID
Q80ZA3
-
Gene Name
Serpinf1; Dmrs91; rCG_34442
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the rat Serpinf1 (NP_808788.1) (Met1-Thr418) was expressed with a polyhistidine tag at the C-terminus.
-
Protein Species
Rat
-
Molecular weight
The recombinant rat Serpinf1 consists 410 amino acids and predicts a molecular mass of 45.9 kDa.
-
Purity
> 90 % as determined by SDS-PAGE.
-
Validations
Rat SerpinF1 / PEDF Protein (His Tag)
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"