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Product Name
Mouse PEDF (His Tag) recombinant protein
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Description
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
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Protein name
Pigment epithelium-derived factor
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Protein short names
RP23-384C18.1; OI12; PEDF; AI195227; PEDFL; SERPINF1; SDF3; OI6; PIG35; EPC-1
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Uniprot ID
P97298
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Gene Name
Serpinf1; Pedf; Sdf3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Thr 417) of mouse SerpinF1 (NP_035470.3) precursor was expressed with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse SerpinF1consists of 409 amino acids and has a calculated molecular mass of 45.8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 60-65 kDa protein in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA.
Immobilized mouse SERPINF1-His at 10 μg/ml (100 μl/well) can bind biotinylated human GST-CSNK2A1 (Cat:500524) with a linear range of 0.31-2.5 μg/ml. -
Validations
Mouse SerpinF1 / PEDF Protein (His Tag) SDS-PAGE
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