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Human TNFSF10/TRAIL/APO-2L (CD253) recombinant protein

Cat.#: 501935

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Product Information

  • Product Name
    Human TNFSF10/TRAIL/APO-2L (CD253) recombinant protein
  • Documents
  • Description
    Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
  • Protein name
    Tumor necrosis factor ligand superfamily member 10
  • Protein short names
    APO-2L; TNFSF10; AI448571; TRAIL; APO2L; TL2; LY81; CD253; A330042I21RIK
  • Uniprot ID
    Q6IBA9
  • Gene Name
    TNFSF10; APO2L; TRAIL
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human TNFSF10 (NP_003801.1) (Val 114-Gly 281) with an initial Met was expressed and purified.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human TNFSF10 consisting of 169 amino acids and has a calculated molecular mass of 19.6 kDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    1. Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 2-10 ng/ml.
    2. Measured in a cytotoxicity assay using NCI-H460 cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 0.2-0.8 ng/ml.
  • Validations

    Human TNFSF10 / TRAIL / APO-2L / CD253 Protein SDS-PAGE

    Human TNFSF10 / TRAIL / APO-2L / CD253 Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"