Anti-TNFSF10/TRAIL/APO-2L (CD253) antibody

Cat.#: 101037

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Product Information

  • Product Name
    Anti-TNFSF10/TRAIL/APO-2L (CD253) antibody
  • Documents
  • Description
    Rabbit polyclonal to TNFSF10/TRAIL/APO-2L (CD253)
  • Tested applications
  • Species reactivity
    Mouse TNFSF10 / TRAIL / APO-2L (CD253)
  • Alternative names
    TL2 antibody; APO2L antibody; CD253 antibody; TRAIL antibody; Apo-2L antibody; TL2 antibody; Ly81 antibody; Trail antibody; APO-2L antibody; AI448571 antibody; A330042I21Rik antibody; A330042I21Rik antibody; AI448571 antibody; APO2L antibody; Apo-2L antibody; APO-2L antibody; CD253 antibody; Ly81 antibody; TL2 antibody; TL2 antibody; Tnfsf10 antibody; TNFSF10 antibody; Trail antibody; TRAIL antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse TNFSF10 / TRAIL / APO-2L (CD253) (rh TNFSF10 / TRAIL / APO-2L (CD253); P50592; Pro118-Asn291). TNFSF10 / TRAIL / APO-2L (CD253) specific IgG was purified by Mouse TNFSF10 / TRAIL / APO-2L (CD253) affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 10-20 μg/ml

    ELISA:0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse TNFSF10 / TRAIL / APO-2L (CD253). The detection limit for Mouse TNFSF10 / TRAIL / APO-2L (CD253) is < 0.039 ng/well.

  • Validations

    TNFSF10 / TRAIL / APO-2L (CD253) Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    TNFSF10 / TRAIL / APO-2L (CD253) Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

  • Background
    Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion TNFSF10 / Apo-2L / CD253 / TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A / TRAILR1, TNFRSF10B / TRAILR2, TNFRSF10C / TRAILR3, TNFRSF10D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 / TRAIL may be modulated by binding to the decoy receptors TNFRSF10C / TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8 / JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • References
    • Song C, et al. (2005) TRAIL (CD253), a new member of the TNF superfamily. J Biol Regul Homeost Agents. 19(1-2): 73-7.
    • Kuribayashi K, et al. (2008) TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther. 7(12): 2034-8.
    • Wiley SR, et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 3(6): 673-82.