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Product Name
Mouse Thioredoxin/TXN/SASP recombinant protein
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Description
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
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Protein name
Thioredoxin
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Protein short names
TXN1; RP11-427L11.1; RP23-332H16.1; TXN; AW550880; ADF; TRX; TRX1; MGC61975; THIOREDOXIN; DKFZP686B1993
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Uniprot ID
P10639
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Gene Name
Txn; Txn1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Txn (P10639) (Met1-Val105) was expressed and purified.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Txn consists of 105 amino acids and predicts a molecular mass of 11.7 KDa. It migrates as an approximately 15 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to catalyze the reduction of insulin. The reaction leads to precipitation, which can be measured by absorbance at 650 nm.
The specific activity is >4 A650/min/mg. -
Validations
Mouse Thioredoxin / TXN / SASP Protein SDS-PAGE
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