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  • Mouse SHH / Sonic hedgehog (His Tag) recombinant protein

Mouse SHH / Sonic hedgehog (His Tag) recombinant protein

Cat.#: 501040

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Product Information

  • Product Name
    Mouse SHH / Sonic hedgehog (His Tag) recombinant protein
  • Documents
  • Description
    Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO.
  • Protein name
    Sonic hedgehog protein
  • Protein short names
    SONIC HEDGEHOG HOMOLOG; HX; TPT; HXL3; HLP3; HHG1; HPE3; SMMCI; MCOPCB5; HEMIMELIC EXTRA TOES; M100081; DSH; 9530036O11RIK; SHORT DIGITS; HHG-1; SONIC HEDGEHOG PROTEIN; TPTPS
  • Uniprot ID
    Q62226
  • Gene Name
    Shh; Hhg1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse SHH (Q62226) (Met1-Gly198) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse SHH comprises 185 amino acids and has a predicted molecular mass of 21 kDa. The apparent molecular mass of the protein is approximately 23 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to induce alkaline phosphatase production by C3H10T1/2 mouse embryonic fibroblast cells. Nakamura, T. et al. (1997) Biochem. Biophys. Res. Commun.237:465.
    The ED50 for this effect is typically 5-40 μg/mL.
  • Validations

    Mouse SHH / Sonic hedgehog Protein (His Tag) SDS-PAGE

    Mouse SHH / Sonic hedgehog Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"