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Product Name
Human SERPINB3 / SCCA-1 (His Tag) recombinant protein
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Description
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
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Protein name
Serpin B3
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Protein short names
SCCA-PD; CLADE B (OVALBUMIN); PROTEIN T4-A; T4-A; MEMBER 3; SCCA1; SERINE (OR CYSTEINE) PROTEINASE INHIBITOR; SERPIN B3; SQUAMOUS CELL CARCINOMA ANTIGEN 1
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Uniprot ID
P29508
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Gene Name
SERPINB3; SCCA; SCCA1
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human SERPINB3 (AAB20405.1) (Asn 2-Pro 390) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SERPINB3 consists of 408 amino acids and predicts a molecular mass of 46.7 kDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit active Cathepsin L cleavage of a fluorogenice ptide substrate Z-LR-AMC, R&D Systems, Catalog # ES008.
The IC50 is < 5 nM. -
Validations
Human SerpinB3 / SCCA-1 Protein (His Tag) SDS-PAGE
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