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Product Name
Rhesus CD160 (Fc Tag) recombinant protein
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Description
CD160 antigen, also known as Natural killer cell receptor BY55 and CD160, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and small intestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD160+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.
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Protein name
Uncharacterized protein
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Protein short names
NK28; BY55; RP11-373C9.1; NK1; AU045688; CD160; FLJ46513
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Uniprot ID
F7HQP2
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Gene Name
CD160
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus CD160 (XP_001089019.1) (Met1-Leu158) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus CD160 comprises 375 amino acids and has a calculated molecular mass of 41.8 KDa.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Cynomolgus CD160 Protein (Fc Tag) SDS-PAGE
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