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Product Name
Anti-CD160 antibody
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Description
Rabbit polyclonal to CD160
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Tested applications
ELISA, IHC-P
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Species reactivity
Cynomolgus CD160
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Alternative names
NK1 antibody; AU045688 antibody; By55 antibody; BY55 antibody; NK28 antibody; By55 antibody; AU045688 antibody; BY55 antibody; Cd160 antibody; NK1 antibody; NK28 antibody; RP11-373C9.1 antibody; CD160 antibody; FLJ46513 antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Cynomolgus CD160 (rh CD160; Met1-Leu158). CD160 specific IgG was purified by Cynomolgus CD160 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Cynomolgus CD160. The detection limit for Cynomolgus CD160 is < 0.039 ng/well.
IHC-P: 0.1-2 μg/ml
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Background
CD160 antigen, also known as Natural killer cell receptor BY55 and CD160, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and small intestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD160+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.
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References
- Barakonyi A. et al., 2004, J Immunol.173 (9): 5349-54.
- Rabot M. et al., 2006, Transpl Immunol. 17 (1): 36-8.
- Abecassis S. et al., 2007, J Invest Dermatol. 127?(5): 1161-6.
- Giustiniani J.?et al., 2007, J Immunol. 178 (3): 1293-300.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"