Rat CXCL10 recombinant protein (C-His)
CXCL10, also known as crg-2, is a chemokine of the CXC subfamily and ligand for the receptor CXCR3. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL10 has a three-dimensional crystal structure. Its signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. CXCL10 can be secreted by several cell types in response to IFN-γ. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
C-X-C motif chemokine 10
Protein short names
C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Interferon-inducible protein 10; Protein Mob-1; Small-inducible cytokine B10
A DNA sequence encoding the rat CXCL10 (NP_620789.1) (Ile22-Pro98) was expressed with a polyhistidine tag at the C-terminus.
The recombinant rat CXCL10 consists of 87 amino acids and predicts a molecular mass of 10 kDa.
> 95 % as determined by SDS-PAGE.
Rat CXCL10 / Crg-2 Protein 15916
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