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  • CXCL10 Polyclonal Antibody

CXCL10 Polyclonal Antibody

Cat.#: 162149

Special Price 174.2 USD

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Product Information

  • Product Name
    CXCL10 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to CXCL10
  • Tested applications
    WB
  • Species reactivity
    Human
  • Alternative names
    CXCL10 antibody; C7 antibody; IFI10 antibody; INP10 antibody; IP-10 antibody; SCYB10 antibody; crg-2 antibody; gIP-10 antibody; mob-1 antibody; C-X-C motif chemokine 10 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-98 of human CXCL10 (NP_001556.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
  • Validations

    Western blot - CXCL10 Polyclonal Antibody

    Western blot - CXCL10 Polyclonal Antibody

    Western blot analysis of extracts of HeLa cells, using CXCL10 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

  • Background
    Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"