CXCL10 Polyclonal Antibody
Polyclonal antibody to CXCL10
CXCL10 antibody; C7 antibody; IFI10 antibody; INP10 antibody; IP-10 antibody; SCYB10 antibody; crg-2 antibody; gIP-10 antibody; mob-1 antibody; C-X-C motif chemokine 10 antibody
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-98 of human CXCL10 (NP_001556.2).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
WB 1:500 - 1:2000
Western blot - CXCL10 Polyclonal Antibody
Western blot analysis of extracts of HeLa cells, using CXCL10 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
Related Products / Services
- Recombinant Proteins
- cDNA Clones
- Rat CXCL10 recombinant protein (C-His)$167.0
- Mouse CXCL10 recombinant protein (C-His)$167.0
- Human CXCL10/INP10/SCYB10 recombinant protein$237.5
- Human CXCL10/INP10/SCYB10 (Fc & His tag) recombinant protein$274.6
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"