Rat CD59 (Fc Tag) recombinant protein

Rat CD59 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

CD59 glycoprotein

MGC2354; MIN3; CD59; MACIF; EJ30; MAC-IP; MEM43; 1F5; 16.3A5; MIRL; MIN1; HRF-20; FLJ38134; RP24-297H17.1; P18-20; HRF20; MIC11; AA987121; EL32; EJ16; MSK21; MIN2; PROTECTIN; G344; FLJ92039; CD59A

P27274

Cd59

Human Cells

A DNA sequence encoding the rat CD59 (P27274) (Met1-Asn100) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Rat

The recombinant rat CD59 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 319 amino acids and has a predicted molecular mass of 35.8 kDa. The apparent molecular mass of the protein is approximately 40 and 43 kDa in SDS-PAGE under reducing conditions.

(55.3+31.4) % as determined by SDS-PAGE