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Product Name
Human CD59 (His Tag) recombinant protein
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Description
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
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Protein name
CD59 glycoprotein
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Protein short names
MGC2354; MIN3; MAC-IP; MACIF; EJ30; CD59; 16.3A5; 1F5; MEM43; MIN1; MIRL; HRF20; RP24-297H17.1; FLJ38134; P18-20; HRF-20; EJ16; EL32; AA987121; MIC11; MIN2; MSK21; FLJ92039; CD59A; G344; PROTECTIN
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Uniprot ID
P13987
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Gene Name
CD59; MIC11; MIN1; MIN2; MIN3; MSK21
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human CD59 (P13987-1) (Met 1-Glu 101) without the pro peptide was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CD59 consists of 87 amino acids and has a predicted molecular mass of 10.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCD59 is approximately 13-19 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human CD59 Protein (His Tag) SDS-PAGE
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