Human eIF2C 3/Argonaute3 (His Tag) recombinant protein
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.
Protein short names
AGO3; MGC86946; RP4-789D17.2; C130014L07RIK; EIF2C3; AW048688; FLJ12765; RP23-113P22.6
A DNA sequence encoding the human EIF2C3 (Q9H9G7-1) (Met 1-Ala 860) was expressed, with a polyhistidine tag at the N-terminus.
The recombinant human EIF2C3 consists of 878 amino acids and predicts a molecular mass of 99.6 kDa. It migrates as an approximately 90 kDa band in SDS-PAGE under reducing conditions.
> 88 % as determined by SDS-PAGE
Human AGO3 / Argonaute 3 / EIF2C3 Protein (His Tag) SDS-PAGE
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