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Product Name
Human COX-2/PTGS2 (His Tag) recombinant protein
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Description
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
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Protein name
Prostaglandin G/H synthase 2
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Protein short names
GRIPGHS; PHS-2; COX-2; PGG/HS; PGHS2; PGHS-2; HCOX-2; TIS10; PTGS2; COX2
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Uniprot ID
P35354
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Gene Name
PTGS2; COX2
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human PTGS2 (NP_000954.1) (Met 1-Leu 604) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PTGS2 consists of 597 amino acids and predicts a molecular mass of 68.5 kDa. It migrates as an approximately 66 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human PTGS2 / COX2 / PGHS-2 Protein (His Tag) SDS-PAGE
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