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Product Name
Anti-COX2/Cyclooxygenase 2 Rabbit antibody
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Description
COX2/Cyclooxygenase 2 Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF, FC, IP
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Species reactivity
Human, Mouse
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Alternative names
COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human COX2/Cyclooxygenase 2
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
ICC/IF: 1/50
FC: 1/100
IP: 1/20
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Validations
Western blot detection of COX2/Cyclooxygenase 2 in 3T3 cell lysates using COX2/Cyclooxygenase 2 Rabbit pAb(1:1000 diluted).Predicted band size:69KDa.Observed band size:74KDa.
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Background
Swiss-Prot Acc.P35354.Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
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