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Product Name
Human NCR3?CD337? (His Tag) recombinant protein
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Description
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
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Protein name
Natural cytotoxicity triggering receptor 3
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Protein short names
1C7; NCR3; NKP30; CD337; LY117; DAAP-90L16.3; LST1; MALS
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Uniprot ID
O14931
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Gene Name
NCR3; 1C7; LY117
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Gly 135) of human NCR3 (NP_667341.1) precursor was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human NCR3 consists of 128 amino acids after removal of the signal peptide and has a predicted molecular mass of 14.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NCR3 is approximately 22-28 kDa due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human NCR3 / NKp300 Protein (His Tag) SDS-PAGE
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