-
Product Name
Myosin Light Chain 2 antibody
- Documents
-
Description
Myosin Light Chain 2 Mouse Monoclonal antibody. Positive WB detected in Human heart. Positive IHC detected in human heart tissue. Observed molecular weight by Western-blot: 18 kDa
-
Tested applications
ELISA, WB, IHC
-
Species reactivity
Human,Mouse, Rat; other species not tested.
-
Alternative names
MLC 2 antibody; MLC 2v antibody; MLC2 antibody; MLC2v antibody; MYL2 antibody; Myosin Light Chain 2 antibody
- Immunogen
-
Isotype
Mouse IgG1
-
Preparation
This antibody was obtained by immunization of Myosin Light Chain 2 recombinant protein (Accession Number: NM_000432). Purification method: Protein G purified.
-
Clonality
Monoclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
-
Validations
human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:107319(MYL2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human heart slide using Catalog No:107319(MYL2 Antibody) at dilution of 1:50
Immunohistochemistry of paraffin-embedded human heart slide using Catalog No:107319(MYL2 Antibody) at dilution of 1:50
-
Background
MYL2, also named as MLC-2v and MLC-2, is ventricular/cardiac muscle isoform. Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10). Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 2 (MVC2). MYL2 has been widely used as a marker of mature ventricular cardiomyocytes.
-
References
- Wang Y, Li ZC, Zhang P. Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes. Stem cells (Dayton, Ohio). 33(10):2973-84. 2015.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"