Human MYL2 Recombinant protein (His tag)

Cat.#: 510245

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Product Information

  • Product Name
    Human MYL2 Recombinant protein (His tag)
  • Documents
  • Description
    Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). {UniProtKB:P08733, UniProtKB:P51667}.
  • Protein name
    Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
  • Protein short names
    MLC2
  • Uniprot ID
    P10916
  • Gene Name
    MYL2; MLC2
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human MYL2 (NP_000423.2) 1-166 aa was fused with the polyhistidine tag
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human MYL2 SDS-PAGE

    Recombinant human MYL2 SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"