MRP2 antibody

MRP2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MRP2 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, mouse kidney tissue. Positive IHC detected in human small intestine tissue. Observed molecular weight by Western-blot: 190-250 kDa

ELISA, IHC, WB

Human, Mouse; other species not tested.

ABC30 antibody; ABCC2 antibody; MRP2 antibody

Rabbit IgG

This antibody was obtained by immunization of MRP2 recombinant protein (Accession Number: NM_000392). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Multi-drug resistance protein 2 (MRP2), also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation. (16434545, 18834541, 23045960)

• Zhou M, Huang Y, Cheng Z. Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes. Journal of virological methods. 207:29-37. 2014.