MPO antibody

MPO antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MPO Mouse Monoclonal antibody. Positive WB detected in HL-60 cells. Positive IHC detected in human tonsillitis tissue, human liver tissue. Observed molecular weight by Western-blot: 90 kDa

ELISA, WB, IHC

Human; other species not tested.

MPO antibody; myeloperoxidase antibody

IgA

This antibody was obtained by immunization of MPO recombinant protein (Accession Number: NM_000250). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation, MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities(PMID:17650507). The mRNA is translated into a single protein of 90 kDa, which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains(PMID:12773517). The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit (PMID:3008892). Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing.