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  • Mouse Pdcd1/Pd1 (Fc tag) recombinant protein

Mouse Pdcd1/Pd1 (Fc tag) recombinant protein

Cat.#: 518154

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Product Information

  • Product Name
    Mouse Pdcd1/Pd1 (Fc tag) recombinant protein
  • Documents
  • Description
    Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. This family also include members of CD28, CTLA-4 and ICOS.The mouse Programmed Death-1 protein, encoded by PD-1 gene, comprises four parts including a putative 20 aa signal peptide, a 149 aa extracellular region, a 21 aa transmembrane domain and a 98 aa cytoplasmic region. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.
  • Protein name
    programmed cell death 1(Pdcd1)
  • Protein short names
    Pd1
  • Uniprot ID
    Q02242
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Pdcd1/Pd1 Leu25-Gln167 is expressed with a Fc tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Pdcd1/Pd1 (Fc tag) recombinant protein

    Mouse Pdcd1/Pd1 (Fc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"