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  • Human PDCD1/PD1 (mFc tag) recombinant protein

Human PDCD1/PD1 (mFc tag) recombinant protein

Cat.#: 519820

Special Price 265.0 USD

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Product Information

  • Product Name
    Human PDCD1/PD1 (mFc tag) recombinant protein
  • Documents
  • Description
    Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
  • Protein name
    programmed cell death 1(PDCD1)
  • Protein short names
    PD1
  • Uniprot ID
    Q15116
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human PDCD1/PD1 Leu25-Gln167 is expressed with a mFc tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human PDCD1/PD1 (mFc tag) recombinant protein

    Human PDCD1/PD1 (mFc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"