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Product Name
Human TIMP-1/TIMP1 recombinant protein
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Description
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
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Protein name
Metalloproteinase inhibitor 1
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Protein short names
RP1-230G1.3; MGC7143; TIMP-1; TPA-S1; FLJ90373; EPA; TIMP1; CLGI; RP23-132C19.3; EPO; HCI; TIMP
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Uniprot ID
Q6FGX5
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Gene Name
TIMP1; CLGI; TIMP
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human TIMP1 (NP_003245.1) (Cys 24-Ala 207) was expressed.
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Protein Species
Human
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Molecular weight
The recombinant human TIMP1 comprises 184 amino acids with a predicted molecular mass of 21 kDa. It migrates as an approximately 26 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2(R&D Systems, Catalog # ES001). The IC50 value is < 6 nM.
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Validations
Human TIMP-1 / TIMP1 Protein SDS-PAGE
Related Products / Services
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