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Product Name
Rat IL-1R2/CD121b (His Tag) recombinant protein
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Description
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).
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Protein name
Interleukin-1 receptor type 2
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Protein short names
IL-1R-2; CDW121B; IL1RB; IL-1 TYPE II RECEPTOR; CD121 ANTIGEN-LIKE FAMILY MEMBER B; CD121B; INTERLEUKIN-1 RECEPTOR BETA; IL-1R-BETA; IL-1RT2; RATTUS NORVEGICUS; IL1R-2; IL1R2C; IL-1RT-2
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Uniprot ID
P43303
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Gene Name
Il1r2; Il-1r2; Il1rb
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat IL1R2 (P43303) extracellular domain (Met 1-Glu 355) was expressed, fused with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat IL1R2 comprises 353 amino acids and predicts a molecular mass of 39.7 kDa. The apparent molecular mass of the rat IL1R2 is approximately 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind biotinylated Rat IL1B-His (Cat:503638) in a functional ELISA.
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Validations
Rat IL1R2 / IL1RB / CD121b Protein (His Tag) SDS-PAGE
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