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Product Name
Mouse IL-1R2/CD121b (His Tag) recombinant protein
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Description
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).
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Protein name
Interleukin-1 receptor type 2
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Protein short names
IL-1RT-2; IL1R2C; IL1R-2; INTERLEUKIN-1 RECEPTOR BETA; CD121B; RATTUS NORVEGICUS; IL-1RT2; IL-1R-BETA; CDW121B; IL1RB; IL-1R-2; IL-1 TYPE II RECEPTOR; CD121 ANTIGEN-LIKE FAMILY MEMBER B
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Uniprot ID
P27931
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Gene Name
Il1r2; Il-1r2; Il1rb
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse IL1R2 (P27931) (Met1-Glu355) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse IL1R2 comprises 353 amino acids and has a predicted molecular mass of 39.6 kDa. The apparent molecular mass of the protein is approximately 56 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA.
Immobilized mouse IL1R2-His at 10 μg/ml (100 μl/well) can bind biotinylated human IL1B-His (Cat:501519), The EC50 of biotinylated human IL1B-His (Cat:501519) is 0.37-0.85 μg/ml. -
Validations
Mouse IL1R2 / CD121b Protein (His Tag) SDS-PAGE
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