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  • Mouse IL-28B/IFN-lambda-3 (His Tag) recombinant protein

Mouse IL-28B/IFN-lambda-3 (His Tag) recombinant protein

Cat.#: 500375

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Product Information

  • Product Name
    Mouse IL-28B/IFN-lambda-3 (His Tag) recombinant protein
  • Documents
  • Description
    Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
  • Protein name
    Interferon lambda-3
  • Protein short names
    IL28B; INF-ALPHA; IFNL3; IFL-1; IL28C; IL28; INF-LAMBDA; IFN-LAMBDA-3; IL-28B
  • Uniprot ID
    Q8CGK6
  • Gene Name
    Ifnl3; Il28; Il28b
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse Ifnl3 (NP_796370.1) (Met1-Val193) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse Ifnl3 consists 185 amino acids and predicts a molecular mass of 21.1 kDa.
  • Purity
    > (48.9+48.2) % as determined by SDS-PAGE.
  • Activity
    Measured in antiviral assays using HepG2 cells infected with vesicular stomatitis virus.
    The ED50 for this effect is typically 44.6-178.4 ng/mL.
  • Validations

    Mouse IL-28B / IFN-lambda-3 Protein (His Tag) SDS-PAGE

    Mouse IL-28B / IFN-lambda-3 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"