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  • Human IL-28B/IFN-lambda-3 (His Tag) recombinant protein

Human IL-28B/IFN-lambda-3 (His Tag) recombinant protein

Cat.#: 504140

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Product Information

  • Product Name
    Human IL-28B/IFN-lambda-3 (His Tag) recombinant protein
  • Documents
  • Description
    Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFN?) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, is able to increase the percentage of splenic CD8+ T cells in vaccinated animals, and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.
  • Protein name
    Interferon lambda-3
  • Protein short names
    INF-LAMBDA; IL28; IFN-LAMBDA-3; IL-28B; IL28B; INF-ALPHA; IFNL3; IFL-1; IL28C
  • Uniprot ID
    Q8IZI9
  • Gene Name
    IFNL3; IL28B; IL28C; ZCYTO22
  • Source/Expression Host
    Yeast
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human IFNL3 (NP_742151.2) (Val18-Val196) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IFNL3 consists 189 amino acids and predicts a molecular mass of 21.3 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human IL-28B / IFN-lambda-3 Protein (His Tag)

    Human IL-28B / IFN-lambda-3 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"