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Product Name
Human WDR5 Recombinant protein (His tag)
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Description
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. {PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19556245, PubMed:20018852}.
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Protein name
WD repeat-containing protein 5
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Protein short names
BIG3
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Uniprot ID
P61964
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Gene Name
WDR5; BIG3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human WDR5 (NP_060058.1) 1-334 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human WDR5 SDS-PAGE
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