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Product Name
Human TNFRSF10D/DCR2/TRAILR4 (Fc tag) recombinant protein
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Description
Human TRAIL R4 is a type 1, TNF R family membrane protein, which is a receptor for TRAIL (APO2 ligand). TRAIL R4 contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. In the new TNF superfamily nomenclature, TRAIL R4 is referred to as TNFRSF10D. TRAIL R4 is unique among the TRAIL receptors in that its cytoplasmic domain contains a truncated consensus death domain motif. Binding of TRAIL R4 does not result in an apoptotic signal. Overexpression of TRAIL R4 can protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL mediated apoptosis. The human soluble TRAIL R4/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.
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Protein name
TNF receptor superfamily member 10d(TNFRSF10D)
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Protein short names
DCR2; TRAILR4; TRUNDD; UNQ251; PRO288
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Uniprot ID
Q9UBN6
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human TNFRSF10D/DCR2/TRAILR4 Ala56-His211 is expressed with a Fc tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human TNFRSF10D/DCR2/TRAILR4 (Fc tag) recombinant protein
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