Human MICA/PERB11.1 (Fc tag) recombinant protein

Human MICA/PERB11.1 (Fc tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.

MHC class I polypeptide-related sequence A(MICA)

PERB11.1

Q29983

Human Cells

A DNA sequence encoding the Human MICA/PERB11.1 Ala23-Glu308 is expressed with a Fc tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.