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Product Name
Human MCM2 Recombinant protein (GST tag)
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Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. {PubMed:8175912}.
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Protein name
DNA replication licensing factor MCM2
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Protein short names
BM28; CCNL1; CDCL1; KIAA0030
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Uniprot ID
B7Z8Z6
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Gene Name
MCM2; BM28; CCNL1; CDCL1; KIAA0030
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human MCM2 (NP_004517.2) 657-904 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human MCM2 SDS-PAGE
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