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Product Name
Human KMO Recombinant protein (GST tag)
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Description
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. {HAMAP-Rule:MF_03018}.
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Protein name
Kynurenine 3-monooxygenase
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Uniprot ID
Q9BS61
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Gene Name
KMO
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human KMO (NP_001397873.1) 107-407 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human KMO SDS-PAGE
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