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Product Name
Human CDK4 (His tag) recombinant protein
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Description
Cyclin-Dependent Kinase 4 (CDK4) is a member of the CMGC Ser/Thr protein kinase family and CDC2/CDKX subfamily. CDK4 is a component of Cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. These complexes are major integrators of various mitogenenic and antimitogenic signals. It is shown that CDK4 is responsible for the phosphorylation of retinoblastoma gene product (Rb). Defects in CDK4 are a cause of susceptibility to cutaneous Malignant Melanoma Type 3.
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Protein name
cyclin dependent kinase 4(CDK4)
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Uniprot ID
P11802
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human CDK4 Met1-Glu303 is expressed with a 6His, T7 tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human CDK4 (His tag) recombinant protein
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