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  • Human CD27 (His Tag) recombinant protein

Human CD27 (His Tag) recombinant protein

Cat.#: 503763

Special Price 307.5 USD

Availability: In Stock
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Product Information

  • Product Name
    Human CD27 (His Tag) recombinant protein
  • Documents
  • Description
    CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.
  • Protein name
    CD27 antigen
  • Protein short names
    CD27; TNFRSF7; TP55; T14; MGC20393; S152.LPFS2; S152
  • Uniprot ID
    P26842
  • Gene Name
    CD27; TNFRSF7
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CD27(P26842) ( Met 1-Ile192) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human CD27 consists of 183 amino acids and predicts a molecular mass of 20.7 KDa. The apparent molecular mass of the protein is approximately 27 KDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized human CD27-his (Cat:503763) at 10 μg/mL (100 μl/well) can bind biotinylated human CD70-Fc (Cat:502332), The EC50 of biotinylated human CD70-Fc (Cat:502332) is 57-85 ng/mL.
  • Validations

    Human CD27 / TNFRSF7 Protein (His Tag) SDS-PAGE

    Human CD27 / TNFRSF7 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"