Human CD155/PVR (Fc Tag) recombinant protein

Human CD155/PVR (Fc Tag) recombinant protein

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CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

3830421F03RIK; CD155; ME4; TAGE4; PVR; HVED; PVS; TAA1; NECL5; NECL-5; D7ERTD458E

P15151

Human Cells

A DNA sequence encoding the extracellular domain (Met 1-Asn 343) of human CD155 (NP_006496.3) was expressed with the C-terminal fused Fc region of human IgG1.

Human

The recombinant human CD155/Fc is a disulfide-linked homodimer. The reduced monomer consists of 561 amino acids and predicts a molecular mass of 61.8 kDa. As a result of glycosylation, the rhCD155/Fc monomer migrates as approximately 95-105 kDa band in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA. Immobilized human DNAM1 at 2 μg/ml (100 μl/well) can bind human CD155-Fc with a linear ranger of 0.032-0.8 μg/ml.