Human CD155/PVR recombinant protein

Human CD155/PVR recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

NECL-5; NECL5; D7ERTD458E; HVED; TAA1; PVS; TAGE4; PVR; CD155; 3830421F03RIK; ME4

P15151

Human Cells

The mature form of the extracellular domain (Met 1-Asn 343) of human CD155 (NP_006496.3) was expressed and purified, with additional five amino acids (DDDDK) at the C-terminus.

Human

The recombinant human CD155 is a monomeric protein after proteilytic removal of the signal peptide. It consists of 329 amino acids and predicts a molecular mass of 35.7 kDa. As a result of glycosylation, the appqrent molecular mass of rhCD155 is approximately 55-60 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

Measure by its ability to bind with recombinant human DNAM1 / CD226.