Human CD147/EMMPRIN (Fc Tag) recombinant protein

Cat.#: 503552

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Product Information

  • Product Name
    Human CD147/EMMPRIN (Fc Tag) recombinant protein
  • Documents
  • Description
    CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.
  • Protein name
    Basigin
  • Protein short names
    BSG; AI115436; HT-7; 5F7; TCSF; EMMPRIN; AI325119; CD147; BASIGIN; M6; OK
  • Uniprot ID
    Q54A51
  • Gene Name
    BSG; UNQ6505/PRO21383
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-His 205) of human CD147 (NP_940991.1) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant mature human CD147/Fc chimera protein consists of 422 amino acids and has a calculated molecular mass of 46.8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 58-65 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE and SEC-HPLC Analysis.
  • Validations

    Human CD147 / EMMPRIN / Basigin Protein (Fc Tag) SDS-PAGE

    Human CD147 / EMMPRIN / Basigin Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"