Human TrkA/NTRK1 (His Tag) recombinant protein

Human TrkA/NTRK1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

High affinity nerve growth factor receptor

TRK-A; TRKA; NTRK1; C80751; P140-TRKA; TKR; MTC; DKFZP781I14186; TRK; TRK1

P04629

NTRK1; MTC; TRK; TRKA

Human Cells

A DNA sequence encoding the human NTRK1 (NP_002520.2) extracellular domain (Met 1-Pro 382) was expressed with a C-terminal polyhistidine tag.

Human

The recombinant human NTRK1 consists of 361 amino acids and has a predicted molecular mass of 39.5 kDa. As a result of glycosylation, it migrates as an approximately 60-65 kDa band in SDS-PAGE under reducing conditions.

> 98 % as determined by SDS-PAGE