-
Product Name
HEXB antibody
- Documents
-
Description
HEXB Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue. Positive WB detected in Jurkat cells, HEK-293 cells, HeLa cells, mouse kidney tissue, mouse lung tissue. Observed molecular weight by Western-blot: 63kd
-
Tested applications
ELISA, WB, IHC
-
Species reactivity
Human,Mouse,Rat; other species not tested.
-
Alternative names
ENC 1AS antibody; HCC 7 antibody; HEXB antibody; Hexosaminidase subunit B antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of HEXB recombinant protein (Accession Number: NM_000521). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
-
Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:111303(HEXB antibody) at dilution of 1:200
Immunohistochemical of paraffin-embedded human kidney using Catalog No:111303(HEXB antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:111303(HEXB antibody) at dilution of 1:50 (under 40x lens)
-
Background
The HEXB(Beta-hexosaminidase subunit beta) gene encodes the beta subunit of the enzyme hexosaminidase, which is involved in the breakdown of gangliosides. It is responsible for the degradation of GM2 gangliosides, and has a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.It has a calculated molecular mass of about 63 KDa.
-
References
- Bastow ER, Last K, Golub S, Stow JL, Stanley AC, Fosang AJ. Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo. Biology open. 1(4):318-28. 2012.
- Sims-Robinson C, Bakeman A, Rosko A, Glasser R, Feldman EL. The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain. Molecular neurobiology. 2015.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"